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Cell子刊:肥胖可通过菌群损伤记忆

发布日期:2020-10-15
  1.人体研究表明,特的肠道菌群成员和功能,与记忆能力和特定脑区体积相关;

  2.一些厚壁菌和拟杆菌/变形菌成员,分别与记忆能力正、负相关,芳香族氨基酸(AAA)代谢和一碳代谢等相关的菌群功能也与记忆相关;

  3.AAA及其分解代谢物以及甜菜碱在血浆和粪便中的水平,与记忆能力存在关联;

  4.肥胖会影响这些关系,并与记忆损伤相关;

  5.移植肥胖者的菌群会降低受体小鼠的记忆分数,小鼠的短期记忆与大脑的AAA途径、炎症基因表达和特定肠道细菌相关。


  近期研究表明,学习和记忆与肠道菌群及其代谢物存在关联。Cell Metabolism发表的一项最新研究,探索了肠道菌群与记忆功能的关系,以及肥胖带来的影响,表明肠道菌群对芳香族氨基酸的代谢作用,可能对记忆功能有重要影响。


Cell Metabolism      [IF:21.567]
Obesity Impairs Short-Term and Working Memory through Gut Microbial Metabolism of Aromatic Amino Acids

肥胖通过芳香族氨基酸的肠道微生物代谢,损伤短期和工作记忆

10.1016/j.cmet.2020.09.002
10-06, Article

Abstract:

The gut microbiome has been linked to fear extinction learning in animal models. Here, we aimed to explore the gut microbiome and memory domains according to obesity status. A specific microbiome profile associated with short-term memory, working memory, and the volume of the hippocampus and frontal regions of the brain differentially in human subjects with and without obesity. Plasma and fecal levels of aromatic amino acids, their catabolites, and vegetable-derived compounds were longitudinally associated with short-term and working memory. Functionally, microbiota transplantation from human subjects with obesity led to decreased memory scores in mice, aligning this trait from humans with that of recipient mice. RNA sequencing of the medial prefrontal cortex of mice revealed that short-term memory associated with aromatic amino acid pathways, inflammatory genes, and clusters of bacterial species. These results highlight the potential therapeutic value of targeting the gut microbiota for memory impairment, specifically in subjects with obesity.
First Authors:
Maria Arnoriaga Rodríguez,Jordi Mayneris-Perxachs
Correspondence Authors:
Rafael Maldonado,José Manuel Fernández-Real
All Authors:
Maria Arnoriaga Rodríguez,Jordi Mayneris-Perxachs,Aurelijus Burokas,Oren Contreras-Rodríguez,Gerard Blasco,Clàudia Coll,Carles Biarnés,Romina Miranda-Olivos,Jèssica Latorre,José-Maria Moreno-Navarrete,Anna Castells-Nobau,Mònica Sabater,María Encarnación Palomo-Buitrago,Josep Puig,Salvador Pedraza,Jordi Gich,Vicente Pérez-Brocal,Wifredo Ricart,Andrés Moya,Xavier Fernández-Real,Lluís Ramió-Torrentà,Reinald Pamplona,Joaquim Sol,Mariona Jové,Manuel Portero-Otin,Rafael Maldonado,José Manuel Fernández-Real


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